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Combinex® (Levamisole, Triclabendazole)
Product information on this website is for Non-U.S. residents only and is provided by Novartis Animal Health Inc. for general purposes only. Many veterinary products listed are available upon prescription only, and not all such products may be available in all countries. The product information is not intended to provide complete medical information. SHOULD YOUR ANIMAL HAVE A MEDICAL CONDITION, PROMPTLY SEE YOUR OWN VETERINARIAN. WE DO NOT OFFER PERSONALIZED MEDICAL DIAGNOSIS OR ANIMAL-SPECIFIC TREATMENT ADVICE. You should always obtain complete medical information about your veterinary product prescription (including their beneficial medical uses and possible adverse effects) by discussing the appropriate use of any veterinary product directly with the prescribing veterinarian.
Veterinary professionals may obtain complete medical information from the product's information leaflet. Information on these products may vary by country. Animal owners and veterinarians should check with local medical resources and regulatory authorities for information appropriate to their country. In addition, current regulations in many countries limit (or even prohibit in some instances) the ability of Novartis Animal Health Inc. to provide information and/or to respond directly to questions regarding its prescription products. Novartis Animal Health Inc., however, will respond to inquiries from and provide information to your qualified health care professional in accordance with local regulations.
Description
Other Trademarks
ENDEX® / PARSIFAL® / SOFOREN® Plus
Product Type
Oral broadspectrum anthelmintic for the control of round worms and liver flukes in cattle and sheep
Description and Composition
COMBINEX is available as 2 ready-to-use drenches:
- COMBINEX 19.5% for cattle containing 7.5 g of levamisole hydrochloride and 12 g of triclabendazole per 100 ml.
- COMBINEX 8.75% for sheep containing 3.75 g levamisole hydrochloride and 5 g triclabendazole per 100 ml.
Properties
COMBINEX contains the active ingredients levamisole and triclabendazole.
Levamisole is an imidazothiazole. It is a cholinergic agonist leading to spastic paralysis of the nematode. Levamisole is a broad spectrum anthelmintic effective against mature and immature stages of nematodes, including strains resistant to other anthelmintics.
Triclabendazole is a benzimidazole. It binds to tubulin impairing intracellular transport mechanisms and interferes with protein synthesis. Triclabendazole is specifically effective against all 3 stages of Fasciola. The unique efficacy against early immature and immature stages makes COMBINEX particularly useful for the treatment of outbreaks of acute and subacute fasciolosis and for the strategic control of Fasciola infections.
Indications
COMBINEX is indicated for the treatment and control of mature and immature gastrointestinal nematodes (Ostertagia, Haemonchus, Trichostrongylus, Cooperia, Nematodirus, Bunostomum, Gaigeria, Chabertia, Oesophagostomum), lungworms (Dictyocaulus) and all 3 stages of liver fluke (Fasciola) infections in cattle and sheep.
Dosage and Administration
The recommended dose rate is :
- Cattle : 1 ml of COMBINEX 19.5% per 10 kg bodyweight, corresponding to 7.5 mg levamisole hydrochloride and 12 mg triclabendazole per kg.
- Sheep : 1 ml of COMBINEX 8.75 % per 5 kg bodyweight, corresponding to 7.5 mg levamisole hydrochloride and 10 mg triclabendazole per kg.
COMBINEX is given by single oral administration.
When shaken well before use COMBINEX is suitable for use through most types of drenching guns.
Treatment of sick animals suffering from worm infections: When sick animals are treated all other animals with the same history should be treated as well. Possible subsequent administrations should be given according to veterinary advice.
Strategic control: The recommended treatment schedule is adapted in each region to the local epidemiological situation.
Waiting periods
Waiting periods according to national registrations.
Special Precautions and Warnings
Do not contaminate ponds, waterways or ditches with the product or used container.
Formulations and Packages
COMBINEX 19.5% and COMBINEX 8.75% come in plastic bottles containing 0.8, 2.2, 5, 12 and 21 liters depending on country.
U.S. Residents
This is an international website and is intended for residents outside the US.
If you are a Livestock Producer or Veterinarian in the USA, please visit our country specific website.
livestock.novartis.com
For U.S. Resident only
Product Availability
Please note that not all products listed within this site may be available in all countries. Also, prescribing information and indications for products may differ from country to country, so please consult your local veterinarian for local prescribing and any other information you may be interested in.
Locations
Headquartered in Basel, Switzerland, and present in almost 40 countries, Novartis Animal Health employs approximately 2,700 associates worldwide.
Partnerships
Novartis collaborates with many companies and academic institutions to develop new products, acquire platform technologies, and access new markets.