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Denagard® 12.5% Solution (Tiamulin)
Product information on this website is for Non-U.S. residents only and is provided by Novartis Animal Health Inc. for general purposes only. Many veterinary products listed are available upon prescription only, and not all such products may be available in all countries. The product information is not intended to provide complete medical information. SHOULD YOUR ANIMAL HAVE A MEDICAL CONDITION, PROMPTLY SEE YOUR OWN VETERINARIAN. WE DO NOT OFFER PERSONALIZED MEDICAL DIAGNOSIS OR ANIMAL-SPECIFIC TREATMENT ADVICE. You should always obtain complete medical information about your veterinary product prescription (including their beneficial medical uses and possible adverse effects) by discussing the appropriate use of any veterinary product directly with the prescribing veterinarian.
Veterinary professionals may obtain complete medical information from the product's information leaflet. Information on these products may vary by country. Animal owners and veterinarians should check with local medical resources and regulatory authorities for information appropriate to their country. In addition, current regulations in many countries limit (or even prohibit in some instances) the ability of Novartis Animal Health Inc. to provide information and/or to respond directly to questions regarding its prescription products. Novartis Animal Health Inc., however, will respond to inquiries from and provide information to your qualified health care professional in accordance with local regulations.
12.5% Solution
Product Type
Oral antibiotic intended for preventive and therapeutic use in pigs and poultry.
Description and Composition
DENAGARD 12.5% Solution is an aqueous solution containing 125 mg tiamulin hydrogen fumarate per ml of product. It is used for medication in drinking water.
Properties
Tiamulin is a bacteriostatic agent, belonging to the group of pleuromutilins and acts at the ribosomal level to inhibit bacterial protein synthesis. It has a wide spectrum of activity but is particularly active against Brachyspira, Lawsonia and Mycoplasma species. Tiamulin belongs to a category of antibiotics which is not used in human medicine.
Indications
Treatment and prevention of Mycoplasma infections (enzootic pneumonia, chronic respiratory disease), pleuropneumonia and porcine respiratory disease complex.
Denagard is particularly indicated for the treatment of swine dysentery (B.hyodysenteriae)
Dosage and Administration
Pigs:
- Treatment of swine dysentery: 8.8 mg tiamulin hydrogen fumarate / kg bodyweight (equivalent to 10 ml DENAGARD 12.5% Solution per 142 kg bodyweight; inclusion level 0.006% tiamulin) for 3-5 consecutive days
- Treatment of PRDC (porcine respiratory disease complex): 15 – 20 mg tiamulin hydrogen fumarate / kg bodyweight (inclusion level 0.012% - 0.018% tiamulin) for 5 – 10 consecutive days
- Treatment of pleuropneumonia: 20 mg tiamulin hydrogen fumarate / kg bodyweight (inclusion level 0.018% tiamulin) for 5 consecutive days
|
Indications |
Tiamulin (concentration in water in %) |
Product |
Water |
Treatment |
|
Treatment swine dysentery |
0.006 |
1 |
2.1 |
5 |
|
Treatment PRDC |
0.012 / 0.018 |
1 |
1.0 / 0.7 |
5 - 10 |
|
Treatment pleuropneumonia |
0.018 |
1 |
0.7 |
5 |
Chickens:
- Prevention of chronic respiratory disease (CRD) and air sacculitis: 12.5 mg tiamulin hydrogen fumarate / kg bodyweight
- Treatment of chronic respiratory disease (CRD) and air sacculitis: 25 mg tiamulin hydrogen fumarate / kg bodyweight
Turkeys:
- Prevention of infectious sinusitis and air sacculitis: 12.5 mg tiamulin hydrogen fumarate / kg bodyweight
- Treatment of infectious sinusitis and air sacculitis: 25 mg tiamulin hydrogen fumarate / kg bodyweight
|
Indications |
Tiamulin (concentration in water in %) |
Product |
Water |
Treatment |
|
Prevention CRD / air sacculitis / infectious sinusitis |
0.0125 |
1 |
1 |
3 days (1st week of life); 1-2 days every 3-4 weeks |
|
Treatment CRD / air sacculitis / infectious sinusitis |
0.025 |
2 |
1 |
3 – 5 |
Withdrawal Periods
Withdrawal periods according to national registrations.
Special Precautions and Warnings
Do not administer ionophore anticoccidials (salinomycin, monensin, narasin) to pigs and poultry receiving therapeutic doses of DENAGARD. Pigs and poultry should not receive products containing ionophores during or for at least seven days before or after treatment with DENAGARD.
Formulations and Packages
DENAGARD 12.5% Solution
- 1 litre dispensing packs
Product Availability
Please note that not all products listed within this site may be available in all countries. Also, prescribing information and indications for products may differ from country to country, so please consult your local veterinarian for local prescribing and any other information you may be interested in.
Locations
Headquartered in Basel, Switzerland, and present in almost 40 countries, Novartis Animal Health employs approximately 2,900 associates worldwide.
Partnerships
Novartis collaborates with many companies and academic institutions to develop new products, acquire platform technologies, and access new markets.
Related Info
Visit our international Denagard website to learn more about one of the most potent antibiotics against the key enteric and respiratory infections affecting pigs and poultry..
Denagard Website
(International)