Interceptor® (Milbemycin Oxime)
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Interceptor is an oral broad-spectrum anthelmintic tablet for the prevention of heartworm disease and the control of roundworms, hookworms and whipworms in dogs.
Description and Composition
Oral tablets of 4 strengths are available:
INTERCEPTOR 2.3mg, a tablet containing 2.3 mg of milbemycin oxime.
INTERCEPTOR 5.75mg, a tablet containing 5.75 mg of milbemycin oxime.
INTERCEPTOR 11.5mg, a tablet containing 11.5 mg of milbemycin oxime.
INTERCEPTOR 23mg, a tablet containing 23 mg of milbemycin oxime.
Milbemycin oxime belongs to the group of macrocyclic lactones, isolated from the fermentation of Streptomyces hygroscopicus var. aureolacrimosus. It is active against mites, against larval and adult stages of nematodes as well as against larvae of Dirofilaria immitis.
The activity of milbemycin is related to its action on invertebrate neurotransmission: Milbemycin oxime, like avermectins and other milbemycins, increases nematode and insect membrane permeability to chloride ions via glutamate-gated chloride ion channels (related to vertebrate GABAA and glycine receptors). This leads to hyperpolarisation of the neuromuscular membrane and flaccid paralysis and death of the parasite.
INTERCEPTOR is well tolerated by dogs of all ages and breeds, including Collies and breeding animals.
INTERCEPTOR is indicated for the prevention of heartworm (Dirofilaria immitis) disease and the treatment and control of roundworms (Toxocara canis, Toxascaris leonina), hookworms (Ancylostoma caninum) and whipworms (Trichuris vulpis) in dogs.
In some European countries additional indications for nematodes and mites are available:
Angiostrongylus vasorum, Crenosoma vulpis
Mites: Demodex canis, Sarcoptes, Pneumonyssoides caninum
Dosage and Administration
INTERCEPTOR is given orally at the minimum dose of 0.5 mg milbemycin oxime per kg body weight according to the following table:
Weight of dog
1 to 4 kg
1 tablet of INTERCEPTOR 2.3mg
>4 to 11 kg
1 tablet of INTERCEPTOR 5.75mg
>11 to 23 kg
1 tablet of INTERCEPTOR 11.5mg
>23 to 45 kg
1 tablet of INTERCEPTOR 23mg
Dogs over 45 kg are given an appropriate combination of tablets.
INTERCEPTOR must be given at monthly intervals, preferably on the same date starting within 1 month from the beginningof the heartworm transmission season and continuing until 1 dose after its end. Where heartworm transmission is not seasonal, INTERCEPTOR is given throughout the year. Dogs living in heartworm-free regions and travelling to heartworm risk areas should be treated within 1 month from the beginning of the exposure to transmission. Treatment should be repeated monthly until 1 administration after the end of the exposure risk. If INTERCEPTOR replaces another heartworm prevention the first dose should be given within 1 month after the previous treatment. The tablets can be given directly into the mouth of the dog or in a portion of food.
Special Precautions and Warnings
In heartworm risk areas or if it is known that the dog has been travelling in heartworm risk regions, dogs should be tested for heartworm infection. Heartworm prevention programs should be started only in dogs found to be uninfected.
Formulations and Packages
There are 4 tablet strengths
INTERCEPTOR containing 2.3 mg milbemycin oxime
INTERCEPTOR containing 5.75 mg milbemycin oxime
INTERCEPTOR containing 11.5 mg milbemycin oxime
INTERCEPTOR containing 23 mg milbemycin oxime
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If you are a Consumer or Veterinarian in the USA and have questions about our products, please call:
Novartis Technical Product Services Group
Learn more about Worm Control in Dogs and Cats from independent Non-profit organisations.
Adult worms are 10 to 30 cm in length and about 1 mm in diameter.
Roundworms are the most common worms of dogs and cats.
Hookworms are common parasites of the small intestine of dogs and cats.
Whipworms are common parasites of the large intestine of dogs.