Product Type

Ointment for the topical treatment of acute and chronic otitis externa and dermatological disorders in cats and dogs.

Description and Composition

PANOLOG is an ointment containing: (per ml)

• 100.000 U Nystatin (INN)
• 2.500 U Thiostrepton (INN)
• 2.5 mg Neomycin (INN) as sulphate
• 1.0 mg Triamcinolone acetonide

in a non –irritating oily vehicle: Plastibase®.

Properties

PANOLOG ointment contains the antibiotics neomycin and thiostrepton for broad spectrum activity against gram positive and gram negative bacteria, nystatin, which inhibits yeast and yeast-like fungi (including Malassezia), and triamcinolone acetonide, a steroid with anti-inflammatory, anti-pruritic and anti-allergic activity.

Indications

PANOLOG ointment is indicated for the treatment of acute and chronic otitis externa (including those cases complicated by Malassezia spp. and Candida albicans), anal gland infection in dogs and cats, interdigital cysts in dogs, and dermatitis, including eczematous dermatitis, contact dermatitis and seborrhoeic dermatitis. It is indicated in the management of dermatological disorders characterized by inflammation, particularly those caused, complicated or threatened by bacterial or yeast infections, and other conditions susceptible to corticoid-antibacterial-antifungal therapy. It is useful as an adjunct in the treatment of dermatitis due to parasitic infection.

Clinical trials have demonstrated that Panolog ointment is effective in the treatment of the ear mite, Otodectes cynotis, in the dog and cat. The mode of action is uncertain as none of the components in Panolog ointment have recognised acaricidal activity.

Dosage and Administration

Frequency of administration is dependent on the severity of the condition. For mild inflammation, application may range from once daily to once a week; for severe conditions PANOLOG ointment may be applied two or three times daily, if necessary. Frequency of treatment may be decreased as improvement occurs.

Otitis: Clean ear of impacted cerumen. Inspect canal and remove any foreign bodies such as grass awns, ticks etc.). Instill three to five drops of the ointment. It may be advisable to instill two to three drops of a local anaesthetic into the ear prior to cleaning.

Anal glands and cystic lesions: drain and fill the gland or cyst with ointment

Other dermatological disorders: clean affected areas, removing any encrusted discharge or exudates. Apply the ointment sparingly in a thin film.

Special Precautions and Warnings

Panolog ointment is not indicated for the treatment of deep abscesses or deep seated infections, such as those of the lymphatic system, for which parenteral therapy is indicated.

Standard care is recommended to be certain that the tympanic membrane is not ruptured before instilling any medication into the ear.

During a course of treatment the situation should be reviewd frequently by close veterinary supervision.

Adverse reactions

Panolog has been well tolerated. Cutaneous reactions attributable to its use have been rare. Sensitivity to neomycin may occur. If redness, irritation or swelling persist or increase, discontinue use.

Systemic glucocorticoid side effects are rare following topical use, however systemic absorption of triamcinolone through topical application and by licking may occur, particularly when used over large areas or for extended periods of time. Therefore animals should be monitored closely for signs of polydipsia, polyuria and increased weight gain.

Use during pregnancy or lactation

Use in pregnant animals should be avoided. Administration in early pregnancy in known to have caused foetal abnormalities in laboratory animals. Administration in late pregnancy may cause early parturition or abortion.

Formulations and Packages

PANOLOG is available in 7.5 ml and 15 ml tubes and dropper bottles, and in 100 ml bottles.